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Our Difference is the Science
Fueling Our Pipeline

The scientists of Ymmunobio are innovating cancer treatment with novel therapeutic antibodies. Our science is focused on novel and first-in-class NPTXR antibodies and CEACAM1 immune agonistic antibodies.

Through robust scientific data and strong IP, we have been able to design antibodies that enable CEACAM1 to act as a checkpoint inhibitor and, most importantly, have a direct co-stimulatory effect on immune cells.

 

Our first-in-class NPTXR antibodies directly target various cancers overexpressing NPTXR and selectively kill cancer cells so that healthy tissue is not affected.

 

Our main differentiator is the dual action of our antibodies, in addition to a significant set of in vitro and in vivo data. Ymmunobio’s scientists are advancing research into NPTXR and CEACAM1.

YB-200

CEACAM1

We are currently investigating several CEACAM1/5 antibodies for their broad applicability in solid tumors. Our research targets cell-to-cell communication, in order to promote an increase in efficiency of the immune response to tumor cells.

YB-200

Our dual action lead asset overcomes resistance by directly co-stimulating immune cells. We were able to design antibodies that leverage both aspects of the CEACAM1 physiological but also its pathophysiological role.

Along with instigating cell-to-cell communication, the antibody can also act as a checkpoint inhibitor disrupting the interaction of CEACAM1 on tumor and immune cells. Indications include hepatocellular carcinoma, colon cancer and melanoma. The FDA has granted YB-200 Orphan Drug Designation (ODD) for the treatment of hepatocellullar carcinoma. 

Metastatic colorectal cancer

44%

Less than 50% of patients respond to current immune therapy

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YB-800

NPTXR

Our research into Neuronal Pentraxin Receptors (NPTXR) is focused on its development as a first-in-class monoclonal antibody against tumor markers in GI cancers. The antibody is able to “switch on” apoptosis selectively, and healthy tissue is not affected.

YB-800

Our first–in-class antibody for gastrointestinal tumors is a new target that was discovered through analyses of a large tumor bank.

 

YB-800 is a molecular target therapeutic drug containing a substance that neutralizes or inhibits expression of Neuronal pentraxin receptor (NPTXR) as an active ingredient. Indications for this therapy include stomach cancer, colorectal cancer, breast cancer, lung cancer, pancreatic cancer, or esophageal cancer.

LEAD INDICATION: COLON CANCER

3rd

Most common cancer globally 

2nd

Most deadly cancer

SECONDARY INDICATION: GASTRIC CANCER

5th

Most common cancer globally 

3rd

Most deadly cancer

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